In cardiovascular fields, Li et al have revealed the role of Kcnq1ot1 to induce H9C2 apoptosis in myocardial ischemia/reperfusion (I/R), which is a major cause for AMI [33], while our study focused on molecular mechanism of hypoxia-induced cell damage during the process of HF. Here, KCNQ1OT1 is linked to hydrops fetalis.