MAPT and tauopathy: The positive effects of the 5G2 tau antibody in the PS19 × Thy-1GCaMP6 mice were comparable to our findings with the 4E6 and 8B2 tau antibodies against the P-Ser396, 404 region of tau in the JNPL3-AAV-GCaMP6s model, in particular under running conditions.14,15 In these studies of ours, analyzing the neuronal calcium profile under running conditions is more sensitive than during resting state to detect differences between wild-type and tauopathy mice and for appreciating the functional benefits of tau antibody treatment.