MAPT and tauopathy: Importantly, these beneficial effects were then confirmed in vivo, showing that 5G2 cleared tau in brain interstitial fluid following a single dose as examined by microdialysis in awake JNPL3 tauopathy mice, cleared insoluble tau in the same tauopathy mouse model following a chronic treatment, improved neuronal function in PS19 tauopathy mice, as examined by calcium imaging, cleared tau after an acute treatment, and had an anti-inflammatory effect in PS19 mice.