MAPT and Alzheimer disease: Neuronal Ca2+ dysfunction has for many years been implicated in AD,61,62 and increased Ca2+ influx does have a close link to tau pathology.63–66 Neuronal calcium profile has been examined to some extent in tauopathy mouse models, with most of the studies reporting functional abnormalities.14,15,67–72 We have previously shown that tauopathy-induced Ca2+ dysfunction is most prominent in awake active mice and that imaging these animals before and after acute treatment can reveal its beneficial effect on neuronal function.