MAPT and tauopathy: After 5G2 tau antibody treatment on day 8, all three Ca2+ parameters increased while the animals were running compared to resting (Figures 9D–9F; two-way ANOVA: PS19 resting vs. PS19 running, (D) p = 0.0002; (E) p < 0.0001; and (F) p < 0.0001), analogous to what was observed in the non-tauopathy mice (Figures 8J–8L).