SERPINA3 and brain ischemia: In this study, we assessed the neuroprotective roles of Act A in neuronal ferroptosis following cerebral ischemia employing both in vivo permanent middle cerebral artery occlusion (pMCAO) and in vitro oxygen–glucose deprivation (OGD) models with a heterozygous deficiency of ARIP1 (Arip1−/+) mice.