Studies on Cx30/Cx43 dKO mice have not provided a clear picture of the role of astrocytic GJs in epilepsy, as some reported spontaneous epileptiform activity in hippocampal slices and increased seizure susceptibility in a chronic TLE model [11, 18], while another study showed reduced sensitivity to PTZ-induced hyperexcitability [19]. This evidence concerns the gene GJA1 and epilepsy.