Our study demonstrates that vosoritide/cGMP-induced PDE2 activation modulates acute pro-arrhythmic Ca2+ events in diabetic cardiomyopathy induced by β-adrenergic stress and I/R, but does not address prevention or reversal of cardiac remodelling of Ca2+ cycling proteins in diabetic cardiomyopathy. The gene discussed is CA2; the disease is diabetic cardiomyopathy.