LEP and obesity due to melanocortin 4 receptor deficiency: Moreover, individuals with weight gain and WC gain should also be given attention, as their combined general obesity and abdominal adiposity may impose a higher risk of HF compared to those maintaining stable weight and WC, likely through pathways involving FFA accumulation [28] and release of pro‐inflammatory cytokines, including leptin, tumour necrosis factor‐alpha and interleukin‐6 [29].