Specifically, ZNF25 was suggested as a candidate gene for osteoblast differentiation in humans (Twine et al., 2016), KLHL14 as a candidate gene for bone strength in chicken (Yue et al., 2022), and ATP9B as a candidate gene regulating the progression of osteoarthritis (Zhou et al., 2018). This evidence concerns the gene ZNF25 and osteoarthritis.