Functional enrichment, protein-protein interaction (PPI) networks, and Cox regression analyses were employed to elucidate pathways and prognostic biomarkers.<h4>Results</h4>We identified 28 shared DEGs between TC and T2D, with CD44, TGFBI, RUNX2, and GJA1 as key hub genes. The gene discussed is TGFBI; the disease is type 2 diabetes mellitus.