CRP and obesity due to melanocortin 4 receptor deficiency: The most prominent differences were observed at age 51–65 when female patients showed significantly higher frequencies of comorbid diseases and conditions (asthma, thyroid, autoimmune and gastrointestinal disease, obesity and elevated CRP; Table S6, Figure 1), angioedema, concomitant CIndU, systemic symptoms, sleep disturbance and emergency referrals (Figure 2), low baseline UCT (Figure 3), high CU‐2QoL scores (Figure 3; p < 0.05 for all comparisons; Table S7) than males.