Compared to high CD4+ cell counts (>500 cells/μL), <200 cells/μL (aOR 12.90, 95% CI 8.84–18.82) and 200–500 cells/μL (aOR 3.08, 95% CI 2.12–4.48) were associated with higher odds of TB diagnosis. The gene discussed is CD4; the disease is tuberculosis.