According to our analysis, SHFM4 mutations (n = 152) and EEC3‐like syndrome mutations share the same triad symptom hierarchy (ectrodactyly>ectodermal dysplasia>cleft lip/palate), though with differential frequencies (SHFM4: 91%, 30%, 7%; EEC3: 68%, 50%, 37%) and dissimilar ectodermal dysplasia patterns (Table S1; Rinne et al. 2006). The gene discussed is TP63; the disease is Ectrodactyly.