The ectrodactyly‐ectodermal dysplasia‐cleft lip/palate syndrome 3 (EEC3, OMIM# 604292) is considered the prototype of TP63‐related disorders and is defined by the triad of ectrodactyly, ectodermal dysplasia, and cleft lip/palate. Here, TP63 is linked to split hand-foot malformation.