NFKB1 and early-onset autosomal dominant Alzheimer disease: In addition, profilins have been demonstrated to be overexpressed in response to processes that promote the production of reactive oxygen species, such as the AGE receptor (RAGE), activating Protein kinase C and NF‐κB pathways, in Alzheimer's disease[58] and patients experiencing hyperglycaemia,[59, 60] thereby inducing an inflammatory response,