To probe the impact of postischemic increase of α-Syn expression and perivascular localization, we assessed the expression of ICAM-1 (intercellular adhesion molecule-1), MMP-9 (matrix metallopeptidase 9), VEGF-A (vascular endothelial growth factor A), and VEGFR-1 (vascular endothelial growth factor receptor 1), which are key genes involved in endothelial activation, immune cell infiltration, basement membrane degradation and vascular permeability after ischemic stroke. This evidence concerns the gene MMP9 and ischemic stroke.