MMP9 and stroke disorder: This is in line with a recent evidence indicating that pathological accumulation of mutant α-Syn in neurons impaired neuronal activity, angiogenesis, and cerebrovascular development in young mice.13 It has been described that MMP-935 and IL-636 exert a beneficial effect in the late-phase of stroke by promoting vascular remodeling.35 Interestingly, we observed that 7 days after tMCAo α-Syn null mice exhibited increase in MMP9 and IL-6 expression that could thus justify the enhanced vascular recovery in these animals, when compared with C57BL/6J mice.