Several studies have shown that NUCB2/nesfatin-1 is expressed in various malignancies, including gastric, breast, prostate, and clear cell renal cell cancers (Kalnina et al. 2009; Kmiecik et al. 2021; Chinapayan et al. 2022; Kmiecik et al. 2022). This evidence concerns the gene NUCB2 and clear cell renal carcinoma.