Similarly, nesfatin-1 suppresses the growth of H295R, a human adrenal carcinoma cell line, by promoting apoptosis, possibly through the regulation of pro- and anti-apoptotic genes, including Bax, BCL-XL, and BCL-2, as well as ERK1/2, p38, and JNK1/2 signaling cascades (Ramanjaneya et al. 2015). This evidence concerns the gene MAPK3 and adrenal carcinoma.