The autoantibodies are lupus anticoagulant (LA), anticardiolipin antibodies (aCL), and anti-β2-glycoprotein I (aβ2GPI) antibodies [1], of which LA has the highest predisposition to cause vascular events. Venous thrombosis, particularly deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common manifestation; arterial events are most frequently observed affecting cerebral circulation. [2]. The gene discussed is ACLY; the disease is deep vein thrombosis.