A hypercoagulability workup revealed primary antiphospholipid syndrome (APS) with positive lupus anticoagulant and beta-2 glycoprotein antibodies, along with a compound heterozygous methylenetetrahydrofolate reductase (MTHFR) mutation and hyperhomocysteinemia. This evidence concerns the gene MTHFR and autoimmune polyendocrinopathy.