Key elements include transient LV dysfunction with RWMAs typically extending beyond a single coronary artery distribution, possible but not obligatory emotional or physical stressor, neurological disorders and pheochromocytoma as potential triggers, new ECG changes such as ST-segment shifts or T wave inversions, moderate elevation of cardiac enzymes and significantly elevated B-type natriuretic peptide (BNP), absence of infectious myocarditis, presence of coronary artery disease not excluding TTC, and a predominance among postmenopausal women. The gene discussed is NPPB; the disease is coronary artery disorder.