A strong correlation with underlying small cell lung carcinoma (SCLC) has also been found, but there is uncertainty in long-term cancer screening [1-4]. Additional studies are emerging regarding identifying cases associated with malignancy with the new additional subgroup of antibodies, such as the potassium channel tetramerization domain containing 16 (KCTD16) [5]. The gene discussed is KCTD16; the disease is small cell lung carcinoma.