GDF2 and obesity due to melanocortin 4 receptor deficiency: In addition, a SOMA scan proteomic analysis with BMI matched group between PCOS and controls, revealed an upregulation in several obesity related proteins including: angiopoietin-1 (ANGPT1), Interleukin-1 receptor antagonist protein (IL-1Ra), and lymphotactin, while several cardioprotective proteins resulted downregulated as soluble receptor for advanced glycation end-products (sRAGE), bone morphogenetic protein 6 (BMP6), manganese superoxide dismutase (MnSOD), and growth/differentiation factor 2 (GDF2) (34).