We performed a comprehensive pan-cancer transcriptomic analysis and found that PTHLH expression strongly correlates with a HIF transcriptional signature across multiple tumor types, with particularly strong associations in head and neck squamous cell carcinoma (HNSC) and lung squamous cell carcinoma (LUSC) (Extended Data Fig. 7f-m). Here, PTHLH is linked to head and neck squamous cell carcinoma.