In addition to Ucp1 induction, white adipocytes in vehicle-treated OSRC-2 tumor-bearing mice exhibited the hallmark switch from unilocular lipid-storing white adipocytes to multilocular thermogenic brown/beige adipocytes, a process that was blocked upon PT2399 treatment (Fig. 1j,k and Extended Data Fig. 1o). This evidence concerns the gene UCP1 and neoplasm.