Individuals in the highest quartile of global pathology had significantly elevated mural cell FN1 expression compared to the remaining individuals (1.33 ± 0.11-fold increase relative to the low pathology group, p = 0.0114; Extended Data 5C), suggesting a link between APOE4-driven fibronectin deposition and AD pathology. This evidence concerns the gene FN1 and Alzheimer disease.