Independent risk factors associated with the development of DFU infections and amputation are variable, and include peripheral neuropathy, peripheral arterial disease (PAD), periwound edema, wound area, wound depth, elevated C-reactive protein, polymicrobial infections, extended spectrum beta-lactamase-producing Gram-negative bacterium, hospital admission for DFUs, and vancomycin treatment (3–6). Here, CRP is linked to peripheral arterial disease.