OTUD5 and pachyonychia congenita: To confirm on-target drug effects, synergism between Duocarmycin TM and A-1331852 was further verified using the drug analogs WEHI-539 (Bxl-xL inhibitor) and seco-DUBA (duocarmycin analog) in a panel of eight PC cell lines (Figure 3E, S6, S7).