CFTR and cystic fibrosis: CFTR misfolding results in the perturbation of hundreds of protein-protein interactions,9,10,25 and the pharmacological suppression of aberrant interactions appears to be a key determinant of the sensitivity of CF variants.26 Importantly, knocking down certain interactors can also suppress misfolding and enhance the pharmacological response,9,10,27–30 which suggests many of these interactions limit therapeutic rescue.