In thyroid cancer, the synergistic interaction between the ERK and PI3K/Akt pathways leads to the epigenetic silencing of genes like PTEN, promoting tumor cell survival and invasion (Gómez Sáez, 2011[41]; Brzezianska and Pastuszak-Lewandoska, 2011[14]). The gene discussed is AKT1; the disease is neoplasm.