Following this, in terms of KEGG pathways, the top ten pathways identified were the NOD-like receptor signaling pathway, TNF signaling pathway, IL - 17 signaling pathway, Rheumatoid arthritis, Viral protein interaction with cytokine and cytokine receptor, AGE-RAGE signaling pathway in diabetic complications, NF-kappa B signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Chemokine signaling pathway, and Legionellosis. Here, TNF is linked to rheumatoid arthritis.