In a study of the correlation between HSP and KIFs, mutations at the p.R204, p.N256, and p.R280 loci of the KIF5A gene are found to be associated with typical HSP symptoms (Carosi et al., 2015), and mutations at different loci are accompanied by a number of other symptoms, including sensorimotor neuropathy or cerebellar ataxia (Tessa et al., 2008; Liu et al., 2014; Cuchanski and Baldwin, 2018; Hong et al., 2023). The gene discussed is KIF5A; the disease is hereditary spastic paraplegia.