These results are consistent with known roles autophagy has played in contributing to a tumorigenic environment, such as the protective role of autophagy in the presence of DNA damage36 and its role in maintaining chromosomal stability.73–75 Our results show an upregulation of UVRAG, an ATG gene involved in chromosomal stability, which is in line with an increased DDR reported in mIDH1 gliomas.15,16 Conversely, this phenomenon could increase cell protection against DNA damage assault and contribute to radio-resistance. This evidence concerns the gene UVRAG and glioma.