Furthermore, when we treated two different mIDH1 mouse glioma cell models with α-ketoglutarate (α-KG) (Fig. 7a), we found that the mIDH1 cells reverted the expression patterns showing significant reduction in several key autophagy regulators including pATG4b, UVRAG, ATG7, and ATG9b (Figs. 7b–k). This evidence concerns the gene ATG7 and central nervous system cancer.