Furthermore, when we treated two different mIDH1 mouse glioma cell models with α-ketoglutarate (α-KG) (Fig. 7a), we found that the mIDH1 cells reverted the expression patterns showing significant reduction in several key autophagy regulators including pATG4b, UVRAG, ATG7, and ATG9b (Figs. 7b–k). The gene discussed is UVRAG; the disease is glioma.