ATG7 and central nervous system cancer: We demonstrate that targeting the autophagy pathway by synthetic protein nanoparticles (SPNPs) incapsulating siRNA against ATG7 enhanced radiosensitivity in mIDH1 mouse glioma model, prolonged survival, and resulted in a sustained immunological memory.43,44 Our findings highlight that autophagy inhibition combined with ionizing radiation (IR) represents an attractive therapeutic strategy that could be implemented for mIDH1 glioma patients.