We demonstrate that targeting the autophagy pathway by synthetic protein nanoparticles (SPNPs) incapsulating siRNA against ATG7 enhanced radiosensitivity in mIDH1 mouse glioma model, prolonged survival, and resulted in a sustained immunological memory.43,44 Our findings highlight that autophagy inhibition combined with ionizing radiation (IR) represents an attractive therapeutic strategy that could be implemented for mIDH1 glioma patients. The gene discussed is ATG7; the disease is glioma.