IDH1 and central nervous system cancer: WT-IDH1 NS and mIDH1 human glioma cells treated with mIDH1 inhibitor AGI-5198 (SF10602+AGI5198) showed a typical mitochondrial fusion morphology, whereas mIDH1 mouse (mIDH1 NS) and untreated human glioma cells (SF10602) presented a mitochondrial morphology corresponding to fission state (Fig. 5k).