NR3C1 and Mental deterioration: Among the observed associations, lower methylation at cg24052866 (NR3C1) was associated with faster cognitive decline, whilst lower methylation at cg07275757 (NR3C2), cg10993059 (NR3C2), and cg25708981 (NR3C1) was associated with faster brain atrophy, specifically in those individuals with depressive symptoms.