CHRDL1 and myocardial infarction: We have recently shown that the secreted cytokine, Chordin-like 1 (Chrdl1), expressed using AAVs preserved cardiac viability and prevented fibrosis after MI 14 Chrdl1 inhibits extracellular BMP4 15, thus protecting against cardiomyocyte death by inducing cardiomyocyte autophagy 14.