Additionally, we identified 496 mutated genes across all tissue and organoid samples, including those associated with cardiovascular diseases, such as mucin MUC family members 54, collagen type XVIII alpha 1 (COL18A1) 55, ADAMTS7 56, tenascin XB (TNXB) 57, fibronectin type III domain containing 1 (FNDC1) 58, and lysine demethylase 6B (KDM6B, also known as JMJD3) 59. This evidence concerns the gene KDM6B and cardiovascular disorder.