Based on the important position of HCC in metabolic cancer field, the genes related with hepatocarcinogenesis were compiled using the DisGeNET database (https://disgenet.com/), revealing that 5 potential bioavailable targets of VPA, including the key ferroptosis maker PTGS2, overlapped with genes associated with hepatocarcinogenesis (Figure S1H-I). Here, PTGS2 is linked to hepatocellular carcinoma.