Recently, our work discovered that hepatic KIF13B expression levels were negatively correlated with MAFLD progress and KIF13B orchestrated mitochondrial function and de novo lipogenesis (DNL) to maintain liver energy homeostasis by activating AMPK pathway, suggesting that KIF13B plays a critical role in hepatic lipid metabolism and the related metabolic disease 21. Here, KIF13B is linked to metabolic disease.