Next, to identify the potential ubiquitination enzymes responsible for TFEB degradation regulated by KIF13B, we integrated transcriptomic data primary mouse BMDMs and human AAA tissues, revealing six downregulated deubiquitinating enzymes (DUBs), including Usp9x, Usp45, Vcpip1, Usp47, Usp16 and Usp25. Among these, USP9X was the only candidate predicted by the HDOCK database to functionally interact with KIF13B with a high confidence score of 0.9186 (Figure 7C-D). The gene discussed is USP45; the disease is triple-A syndrome.