Our key findings demonstrate that macrophage-specific KIF13B stabilizes transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, via enhancing the deubiquitylation mediated by ubiquitin specific peptidase 9 x-linked (USP9X), to attenuate pro-inflammatory polarization and senescence of macrophages, ultimately suppressing AAA progression. The gene discussed is KIF13B; the disease is triple-A syndrome.