In addition, when compared to healthy control tissues, we also observed a significant decrease in KIF13B expression at both mRNA and protein levels in PPE-induced AAA mouse model as well as in the ANG II-induced AAA murine model in the context of hyperlipidemia by delivering adeno-associated virus 8 (AAV8) expressing PCSK9D337Y through tail vein, followed by a Western diet (WD) challenge (Figure 1F-I). Here, AGT is linked to hyperlipidemia.