Given the critical role of L1CAM in pancreatic cancer PNI, we established a PANC-1 sciatic nerve injection model with circNFIB overexpression and/or lentiviral-mediated L1CAM knockdown (sh-L1CAM) to evaluate the therapeutic potential of L1CAM as a target for PNI intervention. This evidence concerns the gene L1CAM and pancreatic neoplasm.