CRP and myositis disease: Although high ESR and CRP levels could suggest an inflammatory myopathy, the absence of significantly elevated CK levels and a negative serology for the common myositis antibodies (e.g., Jo-1) support ischemic muscle injury (e.g., diabetic myonecrosis) rather than polymyositis or immune-mediated necrotizing myopathy (IMNM) (12, 13).