AD is characterized by multiple pathological mechanisms, including Tau hyper-phosphorylation (Chiasseu et al., 2017; Goedert et al., 1988; Hausrat et al., 2022), mitochondrial dysfunction (Wang et al., 2020; Zhang et al., 2023), synaptic loss (Forner et al., 2017; Pereira et al., 2021; Zhong et al., 2023), and cholinergic system impairment (Giacobini et al., 2022; Hampel et al., 2018; Schumacher et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.