To further understand the specific cellular status of esophageal granular cell tumors, we performed an in-depth analysis of the tumor and its paraneoplastic tissues in this patient using single-cell RNA sequencing (scRNA-seq), which showed that neural-like cell subpopulations were enriched in the tumor, and genes such as SOX10, S100B, NCAM1, SPP1, and STMN1 were significantly upregulated. This evidence concerns the gene NCAM1 and esophageal granular cell tumor.