We investigated the association between rare variants in TNF-related genes and PD using optimized Sequence Kernel Association Test (SKAT-O) across the Accelerating Medicines Partnership – Parkinson’s Disease (AMP-PD), UK Biobank (UKB) including UKB-PD (PD cases and controls), and UKB-PROXY (PD cases, proxy-cases and controls) cohorts. This evidence concerns the gene TNF and Parkinson disease.