CAV1 and cancer: Moreover, Cav1 loss in stromal cells, such as cancer-associated fibroblasts (CAFs), correlates with more aggressive cancer phenotypes, as it promotes the secretion of growth factors and cytokines that drive tumor growth and angiogenesis (Martinez-Outschoorn et al., 2010; Shi et al., 2016; Simpkins et al., 2012; Sotgia et al., 2012; Zhao et al., 2013).