In a broader cancer context, proteomic profiling of EVs from the NCI-60 panel, comprising 60 human cancer cell lines from cancerous tissues such as the brain, colon, breast, kidney, prostate, and ovary, identified Cav1 as a common protein cargo across multiple cancer types, alongside other cancer-specific biomarkers (Hurwitz et al., 2016). Here, CAV1 is linked to cancer.