Remarkably, despite increased levels of stress/heat shock proteins (Hsp60, Hsp70, and Hsp90), a key cellular transcription factor NF-κB-p65, and MDR proteins P-gp and MDR-associated protein 1 (MRP1/ABCC1) resulting from TMZ treatment, CHR co-treatment prevented the increased protein expression profile in glioma cells. Here, PGP is linked to central nervous system cancer.