Subgroup analysis indicated that, compared to CT alone, the combination of THCQ had some advantage in reducing IL-6 levels in both adult (MD = −33.50, 95% CI: −61.52 to −5.47; three trials, 221 participants, I2 = 94%) and pediatric (MD = −35.27, 95% CI: −45.20 to −25.34; one trial, 80 participants for children) sepsis patients. Here, IL6 is linked to Sepsis.