TOP2B and cardiomyopathy: For example,: Anthracyclines (e.g., doxorubicin) damage mitochondria in both cardiac and hepatic cells by inhibiting topoisomerase IIβ and inducing free radical generation, leading to cardiotoxicity (dose-dependent cardiomyopathy) and hepatotoxicity (hepatocyte necrosis) through shared oxidative stress mechanisms (Wu et al., 2022; Balough et al., 2025).