Cancers increase neutrophil proportion through three mechanisms of “inflammatory cytokine release + metabolic dysfunction + treatment toxicity”: Inflammatory cytokines (IL-6, TNF-α) activate systemic inflammation and exacerbate cardio-hepatic interactive injury; Insulin resistance induced by tumors and diabetes inhibits hepatic albumin synthesis; Anthracyclines, anti-VEGF drugs, etc., superimposed on AMI-induced ischemia and hypoxia, trigger dual injury to cardio-hepatic microcirculation. The gene discussed is VEGFA; the disease is diabetes mellitus.