CD4 and Epstein-Barr virus infection: When deeper analysis was assessed to explore the specific T cells contributing to this increase in PI, activated CD8+ T cells (CD8+ HLA-DR+) were higher in the PI compared with NI (p=0.0110, ANOVA, followed by Tukey test) and EC (p=0.0233, ANOVA, followed by Tukey test) (Figure 3C), whereas no differences were observed in activated CD4+ T cells (CD4+ HLA-DR+) in the different EBV infection statuses (p>0.05, KW test).