POSTN and cancer: Mechanistically, POSTN activates integrin–FAK/NF-κB signaling, inducing cytokines (MIP-1β, MCP-1, TNF-α, RANTES), thereby enhancing monocyte chemotaxis and M2 polarization (55); metastases from POSTN-overexpressing SKOV3 cells were enriched in cancer-associated fibroblasts (CAFs) (51).