DHRS11 has emerged as a pleiotropic regulator, with our data reinforcing its dual role in hormone-dependent cancers: while it sustains androgen receptor signaling in prostate cancer (21), its prognostic association in breast cancer (22) suggests tissue-specific modulation of steroid hormone pathways—Given that research has shown that female steroid hormones can reduce the risk of colorectal cancer (CRC) (23), we speculate that DHRS11 may affect CRC by regulating the steroid hormone pathway. Here, DHRS11 is linked to breast cancer.