Our findings corroborate prior reports that BMP5 deficiency occurs in 7.7% of sporadic CRC cases and selectively predicts prognosis in this subtype (20).Mechanistically, the BMP5-mediated suppression of EPSTI1 via Jak-Stat signaling may represent CRC-specific vulnerability, potentially explaining its limited prognostic relevance in other tumors. This evidence concerns the gene EPSTI1 and colorectal carcinoma.