These observations, along with a large spectrum of disease represented by ground glass opacities and pulmonary fibrosis in ILD patients, as well as skin rashes, Raynaud’s phenomena, vasculitis in non-ILD patients (19), suggest that the so-called anti-MDA5+DM is rather a systemic syndrome, defined as anti-MDA5 syndrome – AMD, rather than a proper musculocutaneous disease (11). Here, IFIH1 is linked to age-related macular degeneration.