Subsets defined by KLRG1 expression appear to have distinct functions: KLRG1+ ILC2s can become regulatory, producing IL-10 and inducing tolerance (Figure 2F), while KLRG1- ILC2s are associated with IL-13, CXCL2, and CXCL8 production and neutrophil recruitment, contributing to ARG1-mediated T cell suppression in hepatocellular carcinoma (HCC) (Figure 2G) (164, 165). This evidence concerns the gene IL10 and hepatocellular carcinoma.