CCR6+ ILC3s in the spleen, when stimulated with IL-12, upregulate chemokine receptors such as CCR2, CCR6, CCR7, and CXCR5, leading to increased infiltration of CD8+ T cells, NK cells, NKT cells, and myeloid cells into B16 melanoma tumors (164, 183). Here, CCR6 is linked to melanoma.