In both NSCLC and early-stage colorectal cancer (CRC), higher densities of NCR+ ILC3s correlated with increased TLS formation and elevated expression of LTα, LTβ, and TNF, suggesting that ILC3s contribute to shaping immune-supportive niches within the TME (Figure 3D) (14, 182, 194, 200, 201). This evidence concerns the gene TNF and colorectal carcinoma.