CXCL8 and colorectal carcinoma: Moreover, ILC1s themselves have been shown to secrete vascular endothelial growth factor (VEGF), CXCL8/IL-8, and matrix metalloproteinases (MMPs) in several cancer types, including HCC, CRC, and lung cancer, further promoting angiogenesis and tumor progression (Figure 1H) (168, 174).