IL25 and neoplasm: Under IL-25 stimulation, ILC2s adopt a pro-tumorigenic phenotype, secreting IL-4 and IL-13, which promote M2 macrophage polarization, recruit Tregs, and enhance monocytic myeloid-derived suppressor cell (MDSC) accumulation, all of which suppress cytotoxic T cell responses and enable tumor immune evasion (Figure 2E) (164, 165, 177, 179).