The tumor-derived cytokines such as vascular endothelial growth factor (VEGF), endothelin-1 (ET1), EGF-like domain-containing protein 7 (EGFL7), and fibroblast growth factor 2 (FGF2) downregulate gene expression and protein expression of adhesion molecules and chemoattractants (e.g., CCL2, CXCL10, and CXCL7) resulting into inhibition of the immune cell infiltration (69). This evidence concerns the gene FGF2 and neoplasm.