In addition to soluble TGF−β, RCC-derived exosomes carry TGF−β and immunomodulatory miRNAs (miR−23a, miR−146a), which are internalized by NK cells and lead to the downregulation of activating receptors such as NKG2D, NKp30, and NKp44 (35–38). This evidence concerns the gene TGFB1 and renal cell carcinoma.