Furthermore, a study of 204 NSCLC patients with or without PD-L1 inhibitor monotherapy (43 of whom developed irAEs) revealed a proinflammatory increase in IL-1β and elevated levels of IL-5, IL-8, IL-10, IL-12p70, and granzyme A, along with decreased G-CSF, as predictors of irAEs, including pneumonitis (86). This evidence concerns the gene CSF3 and non-small cell lung carcinoma.