In a cohort of 256 patients undergoing PD-1/PD-L1 treatment, including 29 CIP patients, HLA typing revealed a strong correlation between the incidence of CIP and the germline expression of HLA-B allele 35 and HLA-DRB1 allele 11 (39). Here, PDCD1 is linked to hereditary sensory and autonomic neuropathy.