It suppresses IDO, leading to enhanced intertumoral CD8+ T cell activation and Treg apoptosis, promotes DC maturation and CD8+ T cell infiltration, and inhibits M2 macrophage polarization (63–65).As for fasudil, remodels the tumor immune microenvironment by multiple mechanisms: it enhances phagocytosis by antigen-presenting cells and promotes dendritic cell maturation, leading to potent CD8+ T cell priming and infiltration (66). This evidence concerns the gene CD8A and neoplasm.